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Functional Roles of p38 Mitogen-Activated Protein Kinase in Macrophage-Mediated Inflammatory Responses

Year: 2014
Type: review
Abstract: Inflammation is a natural host defensive process that is largely regulated by macrophages during the innate immune response. Mitogen-activated protein kinases (MAPKs) are proline-directed serine and threonine protein kinases that regulate many physiological and pathophysiological cell responses. p38 MAPKs are key MAPKs involved in the production of inflammatory mediators, including tumor necrosis factor-α (TNF-α) and cyclooxygenase-2 (COX-2). p38 MAPK signaling plays an essential role in regulating cellular processes, especially inflammation. In this paper, we summarize the characteristics of p38 signaling in macrophage-mediated inflammation. In addition, we discuss the potential of using inhibitors targeting p38 expression in macrophages to treat inflammatory diseases.
DOI: 10.1155/2014/352371
Authors: Yanyan Yang, Seung Cheol Kim, Tao Yu, Young-Su Yi, Man Hee Rhee, Gi-Ho Sung, Byong Chul Yoo, Jae Youl Cho
Institutions: Sungkyunkwan University, Ewha Womans University, Ewha Womans University Mokdong Hospital, Kyungpook National University, Rural Development Administration, National Institute of Horticultural and Herbal Science, National Cancer Center
Language: English
Open Access status: gold
Estimated APC paid: $3,040
OpenAlex ID: W2042336339
FWCI: 2.369
Cites: 161
Cited by: 414
Related to: 10