Microbial modulation of host apoptosis and pyroptosis
Year: 2014
Type: editorial
Abstract: Apoptosis and pyroptosis are two common programmed cell death types induced by various microbial infections. Apoptosis is non-inflammatory programmed cell death and can be triggered through intrinsic or extrinsic pathways and with or without the contribution of mitochondria. Pyroptosis is an inflammatory cell death and is typically triggered by caspase-1 after its activation by various inflammasomes. Non-canonical caspase-11-mediated pyroptosis has been identified. A NLRP3 (cryopyrin)-dependent but casepase-1-independent proinflammatory necrosis called pyronecrosis (Willingham et al., 2007), and a caspase-2-dependent but caspase-1-independent proinflammatory cell death (Chen et al., 2011) have also been reported. Microbial pathogens are able to modulate host apoptosis, pyroptosis, and inflammasomes through different triggers and pathways. The promotion and inhibition of host cell death vary and depend on the microbe types, virulence, and phenotypes. In this Special Research Topics issue, recent advances in micro-bial modulation of host programmed cell death, with a special focus on apoptosis and pyroptosis, were captured in a total of 11 research and review articles. The special issue includes three Original Research Articles, five Review Articles, and three Mini Review Articles. Two articles were published for each of the three pathogens: Brucella spp. (Bronner et al., 2013; Pei et al.,
Authors: Yongqun He, Amal O. Amer
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,801
OpenAlex ID: W2045413385