Year: 2013
Type: review
Abstract: The mononuclear phagocyte system regulates tissue homeostasis as well as all phases of tissue injury and repair. To do so changing tissue environments alter the phenotype of tissue macrophages to assure their support for sustaining and amplifying their respective surrounding environment. Interferon-regulatory factors are intracellular signaling elements that determine the maturation and gene transcription of leukocytes. Here we discuss how several among the 9 interferon-regulatory factors contribute to macrophage polarization.
Source: Mediators of Inflammation
DOI: 10.1155/2013/731023
Authors: Roman Günthner, Hans-Joachim Anders
Institutions: LMU Klinikum, Ludwig-Maximilians-Universität München
Language: English
Topic: Immune cells in cancer
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $3,040
Funder: Deutsche Forschungsgemeinschaft
Awards: G2195849059, G4291806723
OpenAlex ID: W2018440551