Work

Obesity and Metabolic Syndrome in Circadian Clock Mutant Mice

Year: 2005

Type: article

Abstract: The CLOCK transcription factor is a key component of the molecular circadian clock within pacemaker neurons of the hypothalamic suprachiasmatic nucleus. We found that homozygous Clock mutant mice have a greatly attenuated diurnal feeding rhythm, are hyperphagic and obese, and develop a metabolic syndrome of hyperleptinemia, hyperlipidemia, hepatic steatosis, hyperglycemia, and hypoinsulinemia. Expression of transcripts encoding selected hypothalamic peptides associated with energy balance was attenuated in the Clock mutant mice. These results suggest that the circadian clock gene network plays an important role in mammalian energy balance.

Source: Science

DOI: 10.1126/science.1108750

Authors: Fred W. Turek, Corinne Joshu, Akira Kohsaka, Emily Lin, Ganka Ivanova, Erin McDearmon, Aaron Laposky, Sue Losee-Olson, Amy Easton, Dalan R. Jensen, Robert H. Eckel, Joseph S. Takahashi, Joseph Bass

Institutions: Northwestern University, Howard Hughes Medical Institute, University of Colorado Denver

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

Funders: Howard Hughes Medical Institute, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Diabetes and Digestive and Kidney Diseases

Awards: GENETIC ANALYSIS OF SLEEP REGULATION IN THE MOUSE, STRESS EFFECTS ON SLEEP: INFLUENCE OF GENES AND GENDER, MOLECULAR COMPONENENTS OF INSULIN RECEPTOR BIOGENESIS, Alterations of Sleep and Circadian Timing in Aging, Impact of Sleep on Feeding and the Metabolic Syndrome, Tissue Specific Regulation of Lipoprotein Lipase

OpenAlex ID: W2147712103

FWCI: 30.34

Cites: 40

Cited by: 2,511

Related to: 10