Office based treatment with buprenorphine plus naloxone, or buprenorphine alone reduces opiate use and craving
Year: 2004
Type: article
Abstract: Fudala PJ, Bridge TP, Herbert S, et al . Office-based treatment of opiate addiction with a sublingual-tablet formulation of buprenorphine and naloxone. N Engl J Med 2003;349:949–58.[OpenUrl][1][CrossRef][2][PubMed][3][Web of Science][4] Q How effective is buprenorphine with or without naloxone in reducing opiate use and craving in people addicted to opiates? ### ![Graphic][5] Design: Multicentre randomised controlled trial. ### ![Graphic][6] Allocation: Unclear. ### ![Graphic][7] Blinding: Double blind. ### ![Graphic][8] Follow up period: Four weeks. ### ![Graphic][9] Setting: Eight centres in the United States; October 1996 to September 1997. ### ![Graphic][10] Patients: Adults aged 18–59 years with opiate dependence (DSM-IV) seeking opiate substitution pharmacotherapy. Exclusions: pregnant or nursing women, primary Axis 1 psychiatric diagnosis (DSM-IV) other than opiate, caffeine, or nicotine dependence, or use of methadone, levomethadyl acetate or naltrexone 14 days before enrolment. ### ![Graphic][11] Intervention: Sublingual tablets of: buprenorphine (16 … [1]: {openurl}?query=rft.jtitle%253DNew%2BEngland%2BJournal%2Bof%2BMedicine%26rft.stitle%253DNEJM%26rft.aulast%253DFudala%26rft.auinit1%253DP.%2BJ.%26rft.volume%253D349%26rft.issue%253D10%26rft.spage%253D949%26rft.epage%253D958%26rft.atitle%253DOffice-Based%2BTreatment%2Bof%2BOpiate%2BAddiction%2Bwith%2Ba%2BSublingual-Tablet%2BFormulation%2Bof%2BBuprenorphine%2Band%2BNaloxone%26rft_id%253Dinfo%253Adoi%252F10.1056%252FNEJMoa022164%26rft_id%253Dinfo%253Apmid%252F12954743%26rft.genre%253Darticle%26rft_val_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Ajournal%26ctx_ver%253DZ39.88-2004%26url_ver%253DZ39.88-2004%26url_ctx_fmt%253Dinfo%253Aofi%252Ffmt%253Akev%253Amtx%253Actx [2]: /lookup/external-ref?access_num=10.1056/NEJMoa022164&link_type=DOI [3]: /lookup/external-ref?access_num=12954743&link_type=MED&atom=%2Febmental%2F7%2F2%2F54.atom [4]: /lookup/external-ref?access_num=000185081400006&link_type=ISI [5]: /embed/inline-graphic-1.gif [6]: /embed/inline-graphic-2.gif [7]: /embed/inline-graphic-3.gif [8]: /embed/inline-graphic-4.gif [9]: /embed/inline-graphic-5.gif [10]: /embed/inline-graphic-6.gif [11]: /embed/inline-graphic-7.gif
Source: Evidence-Based Mental Health
DOI: 10.1136/ebmh.7.2.54
Authors: Linda R Gowing, Olga Lopatko
Institution: The University of Adelaide
Language: English
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W2033793939