Work

Enhanced Production of Farnesol by Candida albicans Treated with Four Azoles

Year: 2004

Type: article

Abstract: The dimorphic fungus Candida albicans excretes farnesol, which is produced enzymatically from the sterol biosynthetic intermediate farnesyl pyrophosphate. Inhibition of C. albicans by four azole antifungals, fluconazole, ketoconazole, miconazole, and clotrimazole, caused elevated farnesol production (10- to 45-fold). Furthermore, farnesol production occurs in both laboratory strains and clinical isolates (J. M. Hornby et al., Appl. Environ. Microbiol. 67:2982-2992, 2001) of C. albicans.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.48.6.2305-2307.2004

Authors: Jacob M. Hornby, Kenneth W. Nickerson

Institution: University of Nebraska–Lincoln

Language: English

Topic: Antifungal resistance and susceptibility

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Science Foundation, Pfizer, Pfizer Pharmaceuticals