Work

Strategies of Intracellular Pathogens for Obtaining Iron from the Environment

Year: 2015

Type: review

Abstract: Most microorganisms are destroyed by the host tissues through processes that usually involve phagocytosis and lysosomal disruption. However, some organisms, called intracellular pathogens, are capable of avoiding destruction by growing inside macrophages or other cells. During infection with intracellular pathogenic microorganisms, the element iron is required by both the host cell and the pathogen that inhabits the host cell. This minireview focuses on how intracellular pathogens use multiple strategies to obtain nutritional iron from the intracellular environment in order to use this element for replication. Additionally, the implications of these mechanisms for iron acquisition in the pathogen-host relationship are discussed.

Source: BioMed Research International

DOI: 10.1155/2015/476534

Authors: Nidia Leon-Sicairos, Ruth Reyes-Cortes, Alma M. Guadrón-Llanos, Jesús Madueña-Molina, Claudia Leon-Sicairos, Adrian Canizalez-Román

Institutions: Universidad Autónoma de Sinaloa, Pediatric Hospital of Sinaloa

Language: English

Topic: Iron Metabolism and Disorders

Subfield: Hematology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680