Work

Molecular mechanisms of the physiological functions of the aryl hydrocarbon (dioxin) receptor, a multifunctional regulator that senses and responds to environmental stimuli

Year: 2010

Type: review

Abstract: The aryl hydrocarbon receptor (AhR) was originally identified as a ligand-activated transcription factor that is involved in the induction of xenobiotic-metabolizing Cytochrome P4501A1 (CYP1A1). For several decades, AhR has been studied in relation to toxicology and pharmacology. With recent discoveries on novel AhR functions, AhR research has expanded into multiple aspects of physiology, such as reproduction, innate immunity and tumor suppression. In this review, we summarize and discuss recent progress in mechanistic and functional studies on AhR with particular emphasis on physiological processes.

Source: Proceedings of the Japan Academy Series B

DOI: 10.2183/pjab.86.40

Authors: Yoshiaki FUJII-KURIYAMA, Kaname KAWAJIRI

Institutions: Tokyo Medical and Dental University, Institute for Quantitative Biosciences, The University of Tokyo, The University of Tokyo, Research Institute for Clinical Oncology, Saitama Cancer Center

Language: English

Topic: Toxic Organic Pollutants Impact

Subfield: Health, Toxicology and Mutagenesis

Field: Environmental Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Japan Science and Technology Agency, Core Research for Evolutional Science and Technology