Work

Effect of Glucose Variability on the Long-Term Risk of Microvascular Complications in Type 1 Diabetes

Year: 2009

Type: article

Abstract: OBJECTIVE: This study analyzed data from the Epidemiology of Diabetes Interventions and Complications (EDIC) study to see whether longer-term follow-up of Diabetes Control and Complications Trial (DCCT) patients reveals a role for glycemic instability in the development of microvascular complications. RESEARCH DESIGN AND METHODS: The mean area under the curve glucose and the within-day glucose variability (SD and mean amplitude of glycemic excursions [MAGE]) during the DCCT were assessed to see whether they contributed to the risk of retinopathy and nephropathy by year 4 of the EDIC. RESULTS: Logistic regression analysis showed that mean glucose during the DCCT and mean A1C during EDIC were independently predictive of retinopathy (each P < 0.001) as well as A1C during EDIC of nephropathy (P = 0.001) development by EDIC year 4. Glucose variability did not add to this (all P > 0.25 using SD or MAGE). CONCLUSIONS: Glucose variability in the DCCT did not predict the development of retinopathy or nephropathy by EDIC year 4.

Source: Diabetes Care

DOI: 10.2337/dc09-0109

Authors: Eric S. Kilpatrick, Alan S. Rigby, Stephen L. Atkin

Institutions: Hull Royal Infirmary, University of Hull, Hull York Medical School

Language: English

Topic: Diabetes Management and Research

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: Diabetes UK, Novo Nordisk, National Institutes of Health, National Center for Research Resources