Work

Effects of obesity on sGCβ1 mediated signaling in white adipose tissue

Year: 2015

Type: article

Abstract: Obesity has reached pandemic proportions with 1.9 billion overweight adults; 600 million of whom are obese [1]. It has been shown that stimulating cyclic 3’-5 ’ guanosine monophosphate (cGMP) signaling is able to promote adi-pose tissue homeostasis in obese mice [2]. Conversely, genetic depletion of cGMP dependent protein kinase 1 (PKG1), causes hepatic inflammation and fasting hypergly-cemia in mice [3]. Furthermore, cGMP signaling is essen-tial for differentiation of preadipocytes to mature adipocytes in vitro [4,5]. PKG1 activation blocks RhoA mediated inhibition of insulin receptor substrate 1 in adi-pocytes in vitro [4,5], thus maintaining insulin sensitivity. The status of cGMP signaling cascade in adipose tissue under obese conditions is not yet fully understood. Here, we examine the functional status of cGMP signaling in

Source: BMC Pharmacology and Toxicology

DOI: 10.1186/2050-6511-16-s1-a83

Authors: Abhishek Sanyal, Linda Sarah Hoffmann, Jennifer Etzrodt, Alexander Pfeifer

Institution: University of Bonn

Language: English

Topic: Adipokines, Inflammation, and Metabolic Diseases

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,090