Work

Inflammation, wound repair, and fibrosis: reassessing the spectrum of tissue injury and resolution

Year: 2012

Type: article

Abstract: Estimates from various disease-specific registries suggest that chronic inflammatory and fibrotic disorders affect a large proportion of the world's population, yet therapies for these conditions are largely ineffective. Recent advances in our collective understanding of mechanisms underlying both physiological and pathological repair of tissue injury are informing new clinical approaches to deal with various human inflammatory and fibrotic diseases. This 2013 Annual Review Issue of The Journal of Pathology offers an up-to-date glimpse of ongoing research in the fields of inflammation, wound healing, and tissue fibrosis, and highlights novel pathways and mechanisms that may be exploited to provide newer, more effective treatments to patients worldwide suffering from these conditions.

Source: The Journal of Pathology

DOI: 10.1002/path.4126

Authors: Eric S White, Alberto R Mantovani

Institutions: University of Michigan, Michigan Medicine, University of Milan, IRCCS Humanitas Research Hospital

Language: English

Topic: Wound Healing and Treatments

Subfield: Surgery

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

Funder: National Heart, Lung, and Blood Institute