Retinoic Acid, under Cerebrospinal Fluid Control, Induces Neurogenesis during Early Brain Development
Year: 2014
Type: article
Abstract: One of the more intriguing subjects in neuroscience is how a precursor or stem cell is induced to differentiate into a neuron. Neurogenesis begins early in brain development and suddenly becomes a very intense process, which is related with the influence of Retinoic Acid. Here, using a biological test (F9-1.8 cells) in chick embryos, we show that “in vivo” embryonic cerebrospinal fluid regulates mesencephalic-rombencephalic Isthmic Retinoic Acid synthesis and this effect has a direct influence on mesencephalic neuroepithelial precursors, inducing a significant increase in neurogenesis. This effect is mediated by the Retinol Binding Protein present in the embryonic cerebrospinal fluid. The knowledge of embryonic neurogenetic stimulus could be useful in the control of adult brain neurogenesis.
Source: Journal of Developmental Biology
DOI: 10.3390/jdb2020072
Authors: M. Alonso, Estela Carnicero, Raquel Carretero, Aníbal De la Mano, Jose Moro, Francisco Lamus, Cristina Martín, Angel Gato
Language: English
Subfield: Developmental Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,172
Funder: Junta de Castilla y León
OpenAlex ID: W2070199802