Contributions of Cell-extrinsic and Cell-intrinsic Factors to the Differentiation of a Neural-crest-derived Neuroendocrine Progenitor Cell
Year: 1990
Type: preprint
Abstract: A central question in developmental neurobiology concerns the mechanisms that generate cellular diversi-ty in the vertebrate nervous ystem. Cell lineage ana-lyses have established that many progenitor cells in the developing nervous system are multipotent (Turner and Cepko 1987; Holt et al. 1988; Wetts and Fraser 1988). However, the mechanisms that control the dif-ferentiation of such progenitor cells are poorly under-stood. It is assumed that both the developmental his-tory of a progenitor cell and its interactions with its local environment influence its final choice of develop-mental fate. Few experimental systems are available, however, in which it has been possible to dissect the relative contributions of these two factors to the dif-ferentiation program. In the vertebrate nervous sys-
Authors: N. Mori, S.J. Birren, R. Stein, D. Stemple, D.J. Vandenbergh, C.W. Wuenschell, D.J. Anderson
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7099624660