Human Diurnal Preference and Circadian Rhythmicity Are Not Associated with the CLOCK 3111C/T Gene Polymorphism
Year: 2011
Type: article
Study design: Observational Study
Abstract: Genetic association studies of the CLOCK 3111C/T polymorphism and diurnal preference have yielded conflicting results since the first report that the 3111C allele was associated with eveningness. The goal of the present study was to investigate the association of this polymorphism with diurnal preference and circadian physiology in a group of 179 individuals, by comparing the frequency of the 3111C allele to diurnal preference, habitual sleep timing, circadian phase markers, and circadian period. We did not find a significant association between this allele and morningness/eveningness or any circadian marker.
Source: Journal of Biological Rhythms
Institutions: Brigham and Women's Hospital, Harvard University
Language: English
Subfield: Endocrine and Autonomic Systems
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
Funders: Brigham and Women's Hospital, Harvard Catalyst, National Space Biomedical Research Institute, National Institutes of Health, National Institute on Aging, National Heart, Lung, and Blood Institute, National Institute of Mental Health, National Institute of Diabetes and Digestive and Kidney Diseases, National Institute of Neurological Disorders and Stroke, National Center for Research Resources, National Center for Complementary and Integrative Health, Air Force Office of Scientific Research
Awards: Disrupted Sleep in the Elderly: Circadian Etiology, G1523888516, Effect of Vitamin B12 on the Human Circadian Pacemaker, G2496518617, Harvard Clinical and Translational Science Center (UL1), Circadian & Genetic Evaluation of Extreme Sleep Timing, Circadian adaptation to non-24-hour sleep-wake schedules, G3740841103, General Clinical Research Center, G4365582495, G455375549, Sleep, Aging and Circadian Rhythm Disorders, Genetic Analysis of Extreme Circadian/Sleep Phenotypes, Neurobiology of Individual Differences in Sleep Duration, Treatment of Circadian Sleep Disorders with Bright Light, Impact of MTNR1B and CRY2 variants on sleep circadian physiology and metabolism, Desensitization of Circadian Responses to Light, Adaptation of Circadian Responses to Light Treatment
OpenAlex ID: W2064736468