Year: 2010
Type: article
Abstract: A long-standing problem in chromosome biology concerns the dynamic nature of centromeres. These chromosomal sites assemble the protein machines called kinetochores that connect chromosomes to the spindle microtubules for segregation to daughter cells during mitosis and meiosis. In multicelluar eukaryotes, centromeres are typically composed of highly homogeneous tandem repeats that evolve rapidly despite their highly conserved function [1]. For tandem repeats to evolve, a mutation must spread by some recombinational process, but a persistent dogma is that centromeres do not undergo homologous chromosome recombination (the shuffling of genetic segments between chromosomal pairs). New evidence [2] challenges this dogma and addresses the problem of rapidly evolving centromeres. The Role of Crossing Over in Meiosis Centromeres do not act alone in orchestrating chromosome
Source: PLoS Biology
Authors: Paul B. Talbert, Steven Henikoff
Institutions: Howard Hughes Medical Institute, Fred Hutch Cancer Center
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $5,500
Funder: Howard Hughes Medical Institute
OpenAlex ID: W2057461162