Hepatitis B Virus Surface Antigen (HBsAg) Mutants in Singapore Adults and Vaccinated Children with High Anti-Hepatitis B Virus Antibody Levels but Negative for HBsAg
Year: 2000
Type: article
Abstract: The hepatitis B virus (HBV) infection rate has been effectively reduced by universal vaccination. Concentrations of vaccine-induced neutralizing antibodies (anti-HBs) above 10 mIU/ml are generally regarded as sufficient for protection against HBV infection (4). The detection of the hepatitis B surface antigen (HBsAg) by enzyme immunoassay (EIA) utilizes either polyclonal and/or monoclonal anti-HBs and targets the major “a” determinant of HBsAg, although other targets may also be available for detection. Such assays may be unable to detect HBsAg “a” determinant mutants (2, 5, 6).
Source: Journal of Clinical Microbiology
Authors: Wei Ning Chen, Chong Jin Oon
Institution: Singapore General Hospital
Language: English
Topic: Hepatitis B Virus Studies
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W1521203842