Year: 2013
Type: review
Abstract: Matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) remodel the pericellular environment by regulating the cleavage of extracellular matrix proteins, cell surface components, neurotransmitter receptors, and growth factors, which together regulate cell adhesion, synaptogenesis, synaptic plasticity, and long-term potentiation. Increased MMP activity and dysregulation of the balance between MMPs and TIMPs have also been implicated in various pathological conditions. Recent studies have suggested that prolonged seizures are associated with high MMP levels in serum and neural tissues, and certain extracellular macromolecule targets may influence the pathogenesis of epilepsy and seizure. In this review, we discuss the roles of MMP activation in animal models of epilepsy.
Authors: Hiroyuki Mizoguchi, Kiyofumi Yamada
Language: English
Subfield: Clinical Neurology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Awards: G2401895177, Research for reward-basis decision making in drug abuse-dependent rat, Effect of drugs of abuse on reward-based decision-making in rodents, Functional analysis of IFITM3 in neurodevelopmental impairments, Comprehensive research of MMP gene in an animal model of epileptic seizure, G7759120944
OpenAlex ID: W2027040745