Work

Colocalization of F-actin and talin during Fc receptor-mediated phagocytosis in mouse macrophages.

Year: 1990

Type: article

Abstract: We have studied the distribution of talin in J774 cells and mouse peritoneal macrophages undergoing Fc receptor-mediated phagocytosis. At early stages of phagocytosis, talin accumulates in the cells' cortical cytoplasm adjacent to the forming phagosome and extends into pseudopods that are encircling the particle. Talin colocalizes with F-actin at these sites. After particle ingestion is completed, F-actin and talin are no longer concentrated adjacent to phagosomes. Thus, talin and F-actin undergo dynamic and coordinate changes in their cytoplasmic location during Fc receptor-mediated phagocytosis.

Source: The Journal of Experimental Medicine

DOI: 10.1084/jem.172.6.1853

Authors: S Greenberg, K Burridge, S C Silverstein

Institution: Columbia University

Language: English

Topic: Phagocytosis and Immune Regulation

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

Open Access status: bronze

Funders: National Institutes of Health, National Institute of General Medical Sciences, National Institute of Allergy and Infectious Diseases

Awards: G1472096069, Cell Adhesion and the Regulation of Rho GTPases, G7148281153