Work

The Role of Synaptic GTPase-Activating Protein in Neuronal Development and Synaptic Plasticity

Year: 2003

Type: article

Abstract: Synaptic GTPase-activating protein (SynGAP) is a neuronal RasGAP (Ras GTPase-activating protein) that is selectively expressed in brain and highly enriched at excitatory synapses, where it negatively regulates Ras activity and its downstream signaling pathways. To investigate the physiological role of SynGAP in the brain, we have generated mutant mice lacking the SynGAP protein. These mice exhibit postnatal lethality, indicating that SynGAP plays a critical role during neuronal development. In addition, cell biological experiments show that neuronal cultures from mutant mice have more synaptic AMPA receptor clusters, suggesting that SynGAP regulates glutamate receptor synaptic targeting. Moreover, electrophysiological studies demonstrated that heterozygous mutant mice have a specific defect in hippocampal long-term potentiation (LTP). These studies show that the regulation of synaptic Ras signaling by SynGAP is important for proper neuronal development and glutamate receptor trafficking and is critical for the induction of LTP.

Source: Journal of Neuroscience

DOI: 10.1523/jneurosci.23-04-01119.2003

Authors: Jee Hae Kim, Hey-Kyoung Lee, Kogo Takamiya, Richard L. Huganir

Institutions: Howard Hughes Medical Institute, Johns Hopkins University, Johns Hopkins Medicine

Language: English

Topic: Neuroscience and Neuropharmacology Research

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

Open Access status: bronze

OpenAlex ID: W2108122441

FWCI: 3.706

Cites: 32

Cited by: 231

Related to: 10