Work

Interference between PARPs and SIRT1: a novel approach to healthy ageing?

Year: 2011

Type: article

Abstract: Poly(ADP-ribosyl) polymerases (PARPs) have traditionally been linked to chromosome maintenance and DNA repair. Recent findings identify PARPs as key modulators of metabolism through their influence on SIRT1 activity, hinting to a possible role of PARPs as longevity regulators.

Source: Aging

DOI: 10.18632/aging.100326

Authors: Carles Cantó, Johan Auwerx

Institution: École Polytechnique Fédérale de Lausanne

Language: English

Topic: Sirtuins and Resveratrol in Medicine

Subfield: Geriatrics and Gerontology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Science Foundation, Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases