Year: 2013
Type: article
Abstract: Depression is a common mental disorder with relatively high life-time prevalence and substantial disability, especially in women [1–3]. Clinical manifestations of depression include loss of interest or pleasure, disturbed sleep or appetite, poor concentration, etc., worst of which is suicide. To solve such an important global public health issue, it is essential to establish ideal animal models for study and treatment of depression. Cynomolgus monkeys have been proved to be advantageous for modeling human depression through mother–infant separation [4] and social subordination stress [5]. Behavioral tests have been performed in animals to test severity of depression and successfulness of modeling, for example, forced swim test and tail suspension test for rodents [6,7] and sucrose intake test for nonhuman primates [8]. In this study, we attempted to establish several behavioral criteria that can be easily
Source: CNS Neuroscience & Therapeutics
DOI: 10.1111/cns.12177
Authors: Bo‐Shi Fan, Yang Sun, Xia Liu, Jian‐Guang Yu
Institution: Second Military Medical University
Language: English
Subfield: Behavioral Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: bronze
Award: G2720984874
OpenAlex ID: W2073952013