Work

Combined Treatment with Anisodamine and Neostigmine Inhibits Joint Inflammation in Collagen‐Induced Arthritis Mice

Year: 2014

Type: article

Abstract: The first two authors contributed equally to this work. Rheumatoid arthritis (RA) is a complicated and treatment refrac-tory autoimmune disease that is characterized by a chronic inflammatory infiltration of immune cells [1]. The central nervous system plays an important role in limiting inflammatory responses via an inflammatory reflex of the vagus nerve termed as “the cho-linergic antiinflammatory pathway ” [2]. Acetylcholine, the princi-pal neurotransmitter of the vagus nerve, interacts with a7 nicotinic acetylcholine receptor (a7nAChR) expressed on macro-phages and other cells and could inhibit the production of proin-flammatory cytokines such as TNFa, interleukin (IL)-1b, and IL-6. Decreased level of vagus nerve activity is correlated with increased serum concentration of late-phase inflammation cytokine high-mobility group box chromosomal protein 1 in patients with RA. Stimulation of nicotinic acetylcholine receptors attenuates colla-

Source: CNS Neuroscience & Therapeutics

DOI: 10.1111/cns.12213

Authors: Jv‐Xiang Zhou, Ping Ke, Gui Huan, Bo‐Zong Shao, Chong Liu

Institution: Second Military Medical University

Language: English

Topic: Vagus Nerve Stimulation Research

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,140