Year: 2007
Type: article
Abstract: © 2007 Cutsuridis et al; licensee BioMed Central Ltd. It has been suggested that the hippocampal theta rhythm can contribute to memory formation by separating encoding and retrieval of memories into different functional cycles [1]. Herein, we investigate via computer simulations the mechanisms by which storage of spatio-temporal input patterns is achieved by the CA1 microcircuitry. A model of the CA1 microcircuitry is presented using biophysical representations of its major cell types including pyramidal cells and three types of inhibitory interneurons: basket cells, chandelier cells and bistratified cells. Inputs to the network come from the medial septum, entorhinal cortex and CA3 Schaffer collaterals. Patterns of CA3 input are stored via an STDP-type learning rule on the pyramidal cell target synapses. The other inputs provide
Source: BMC Neuroscience
Institutions: University of Stirling, University of Glasgow
Language: English
Topic: Memory and Neural Mechanisms
Subfield: Cognitive Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,990
OpenAlex ID: W1990990894