Generation and Regeneration of Cells of the Liver and Pancreas
Year: 2008
Type: review
Abstract: Liver and pancreas progenitors develop from endoderm cells in the embryonic foregut. Shortly after their specification, liver and pancreas progenitors rapidly acquire markedly different cellular functions and regenerative capacities. These changes are elicited by inductive signals and genetic regulatory factors that are highly conserved among vertebrates. Interest in the development and regeneration of the organs has been fueled by the intense need for hepatocytes and pancreatic beta cells in the therapeutic treatment of liver failure and type I diabetes. Studies in diverse model organisms have revealed evolutionarily conserved inductive signals and transcription factor networks that elicit the differentiation of liver and pancreatic cells and provide guidance for how to promote hepatocyte and beta cell differentiation from diverse stem and progenitor cell types.
Source: Science
Authors: Kenneth S. Zaret, Markus Grompe
Institutions: Fox Chase Cancer Center, Oregon Health & Science University
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: green
Awards: Trans-Acting Factors Causing Cell-Specific Gene Control, Transplantation Assay for Liver Repopulating Cells, Novel Reagents For Beta Cell Biology, G4841152554, Gene Regulatory Signals for Beta Cell Development, Trans-acting Factors Causing Cell Specific Gene Control, Comprehensive Cancer Center Program at Fox Chase
OpenAlex ID: W1982786429