Work

ETosis: A Microbicidal Mechanism beyond Cell Death

Year: 2012

Type: article

Abstract: Netosis is a recently described type of neutrophil death occurring with the release to the extracellular milieu of a lattice composed of DNA associated with histones and granular and cytoplasmic proteins. These webs, initially named neutrophil extracellular traps (NETs), ensnare and kill microorganisms. Similarly, other cell types, such as eosinophils, mast cells, and macrophages, can also dye by this mechanism; thus, it was renamed as ETosis, meaning death with release of extracellular traps (ETs). Here, we review the mechanism of NETosis/etosis, emphasizing its role in diseases caused by protozoan parasites, fungi, and viruses.

Source: Journal of Parasitology Research

DOI: 10.1155/2012/929743

Authors: Anderson B. Guimarães-Costa, Michelle T. C. Nascimento, Amanda B. Wardini, Lucia H. Pinto-da-Silva, Elvira M. Saraiva

Institutions: Universidade Federal do Rio de Janeiro, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal Rural do Rio de Janeiro

Language: English

Topic: Neutrophil, Myeloperoxidase and Oxidative Mechanisms

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,000