Work

The separated enantiomers of 2'-deoxy-3'-thiacytidine (BCH 189) both inhibit human immunodeficiency virus replication in vitro

Year: 1992

Type: article

Abstract: Racemic 2'-deoxy-3'-thiacytidine (BCH 189) is a dideoxycytidine analog having a sulfur atom in place of the 3' carbon. The enantiomers of BCH 189 have been resolved and found to be equipotent in antiviral activity against human immunodeficiency virus types 1 and 2. However, the (-)-enantiomer (3TC) is considerably less cytotoxic than the (+)-enantiomer.

Source: Antimicrobial Agents and Chemotherapy

DOI: 10.1128/aac.36.1.202

Authors: J A Coates, N Cammack, H J Jenkinson, I M Mutton, B A Pearson, R Storer, J M Cameron, C R Penn

Language: English

Topic: HIV/AIDS drug development and treatment

Subfield: Infectious Diseases

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W2040962830

FWCI: 27.73

Cites: 15

Cited by: 288

Related to: 10