Work

The circuitry of cargo flux in the ESCRT pathway

Year: 2009

Type: article

Abstract: The endosomal sorting complex required for transport (ESCRT) complexes sort ubiquitinated membrane proteins into multivesicular bodies, which is a key step in the lysosomal degradation pathway. Shields et al. (Shields, S.B., A.J. Oestreich, S. Winistorfer, D. Nguyen, J.A. Payne, D.J. Katzmann, and R. Piper. 2009. J. Cell Biol. 185:213-224) identify a new ubiquitin-binding site in ESCRT-I and provide evidence that the upstream ESCRT-I and -II complexes sort cargo in parallel rather than in series.

Source: The Journal of Cell Biology

DOI: 10.1083/jcb.200903013

Authors: James H. Hurley, Xuefeng Ren

Institutions: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases

Language: English

Topic: Cellular transport and secretion

Subfield: Cell Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Funder: National Institutes of Health

OpenAlex ID: W2120952957

FWCI: 0.804

Cites: 14

Cited by: 20

Related to: 10