Effectiveness of Lifestyle Interventions for Individuals With Severe Obesity and Type 2 Diabetes
Year: 2011
Type: article
Abstract: OBJECTIVE: Rates of severe obesity (BMI ≥40 kg/m(2)) are on the rise, and effective treatment options are needed. We examined the effect of an intensive lifestyle intervention (ILI) on weight loss, cardiovascular disease (CVD) risk, and program adherence in participants with type 2 diabetes who were severely obese compared with overweight (BMI 25 to <30 kg/m(2)), class I (BMI 30 to <35 kg/m(2)), and class II (BMI 35 to <40 kg/m(2)) obese participants. RESEARCH DESIGN AND METHODS: Participants in the Action for Health in Diabetes (Look AHEAD) trial were randomly assigned to ILI or diabetes support and education (DSE). DSE participants received a less intense educational intervention, whereas ILI participants received an intensive behavioral treatment to increase physical activity (PA) and reduce caloric intake. This article focuses on the 2,503 ILI participants (age 58.6 ± 6.8 years). RESULTS: At 1 year, severely obese participants in the ILI group lost -9.04 ± 7.6% of initial body weight, which was significantly greater (P < 0.05) than ILI participants who were overweight (-7.43 ± 5.6%) and comparable to class I (-8.72 ± 6.4%) and class II obese (-8.64 ± 7.4%) participants. All BMI groups had comparable improvements in fitness, PA, LDL cholesterol, triglycerides, blood pressure, fasting glucose, and HbA(1c) at 1 year. ILI treatment session attendance was excellent and did not differ among weight categories (severe obese 80% vs. others 83%; P = 0.43). CONCLUSIONS: Severely obese participants in the ILI group had similar adherence, percentage of weight loss, and improvement in CVD risk compared with less obese participants. Behavioral weight loss programs should be considered an effective option for this population.
Source: Diabetes Care
DOI: 10.2337/dc11-0874
Language: English
Subfield: Endocrinology, Diabetes and Metabolism
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
Awards: G1187123934, G1825392443, G2037811546, G2050560213, Diabetes Research and Training Center, General Clinical Research Center, Action for Health in Diabetes Continuation (Look AHEAD-E), 05/16 Action for Health in Diabetes Extension Study - Research Project, 10/16 Action for Health in Diabetes Extension Study Research Project, General Clinical Research Center, 14/16 Action for Health in Diabetes Extension Study Research Project, 02/16 Action for Health in Diabetes Extension Study Research Study, General Clinical Research Center, General Clinical Research Center, GENERAL CLINICAL RESEARCH CENTER, 16/16 Action for Health in Diabetes Extension Study Biostatistics Research Center, 09/16 Action for Health in Diabetes Extension Study Research Project, 08/16 Action for Health in Diabetes Extension Study Research Project, 07/16 Action for Health in Diabetes Extension Study Research Project, 04/16 Action for Health in Diabetes Extension Study Research Project, JHU-UMD Diabetes Research Center, 03/16 Action for Health in Diabetes Extension Study Research Project, 13/16 Action for Health in Diabetes Extension Study Research Project, 11/16 Action for Health in Diabetes Extension Study Research Project, 15/16 Action for Health in Diabetes Extension Study Research Project, Obesity/Nutrition Research Center, 12/16 Action for Health in Diabetes Extension Study Research Project, 06/16 Action for Health in Diabetes Extension Study Research Project, Diabetes Research Center, Colorado Nutrition Obesity Research Center, G955307958
OpenAlex ID: W2120919105