Molecule of the month: miRNA and proteins DARPP-32, DRD1, SLC6A3, and CK2
Year: 2013
Type: article
Abstract: The dopamine receptor subtype in brain is DRD1. This receptor modulates several cellular functions and its expression has been studied in detail concerning extracellular signaling. A publication [1] indicates that there is also miRNA regulation (suppression) of DRD1 transcription and translation due to miR-142-3p interaction with the DRD1 3'-untranslated region (1,277 bp) of the DRD1 mRNA. This affects dopamine- and cAMP-regulated phosphoprotein of 32 kDa (DARPP-32) expression as well, consequently [1].
Source: Bioinformation
Author: Paul Shapshak
Institutions: University of South Florida, Tampa General Hospital
Language: English
Subfield: Cellular and Molecular Neuroscience
Field: Neuroscience
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W2055040906