Are Anti-inflammatory Therapies Viable Treatments for Psychiatric Disorders?
Year: 2015
Type: article
Abstract: indicate that inflammationmayplay a role in a host of psychiatric illnesses.1 These data re-veal reliable associations of inflammatorymarkerswith psychiatricdisorders, the inductionofpsychiatric symp-toms following administration of inflammatory stimuli, theassociationof inflammation-relatedgeneswithpsy-chiatric disease, and the elucidation of neurobiological and immunological mechanisms by which inflamma-tion targets neurotransmitters and neurocircuits to change behavior. Nevertheless, whether therapeutic strategies that inhibit inflammation will be effective in treatingpsychiatric illnesses remainsunclear. Thisques-tion isnot trivial given thepressingneed fornovel thera-peutics basedon the high rates of treatment resistance across disorders and on our relatively limited psycho-
Source: JAMA Psychiatry
Authors: Andrew H. Miller, Charles L. Raison
Institutions: Emory University, University of Arizona
Language: English
Subfield: Biological Psychiatry
Field: Neuroscience
Domain: Life Sciences
Open Access status: green
Awards: Atlanta Clinical and Translational Science Institute (UL1), Neurobiological and Behavioral Effects of Cytokine Antagonism in Major Depression, Predictors and Targets of Response to Cytokine Antagonism in Depression, Phenotyping Major Depression with Increased Inflammation, Atlanta Clinical and Translational Science Institute (ACTSI) Renewal, Atlanta Clinical and Translational Science Institute (ACTSI) Renewal, Winship Cancer Institute Cancer Center Support Grant
OpenAlex ID: W1997291002