Work

Nrf2 Signaling and the Slowed Aging Phenotype: Evidence from Long-Lived Models

Year: 2015

Type: review

Abstract: Studying long-lived animals provides novel insight into shared characteristics of aging and represents a unique model to elucidate approaches to prevent chronic disease. Oxidant stress underlies many chronic diseases and resistance to stress is a potential mechanism governing slowed aging. The transcription factor nuclear factor (erythroid-derived 2)-like 2 is the "master regulator" of cellular antioxidant defenses. Nrf2 is upregulated by some longevity promoting interventions and may play a role in regulating species longevity. However, Nrf2 expression and activity in long-lived models have not been well described. Here, we review evidence for altered Nrf2 signaling in a variety of slowed aging models that accomplish lifespan extension via pharmacological, nutritional, evolutionary, genetic, and presumably epigenetic means.

Source: Oxidative Medicine and Cellular Longevity

DOI: 10.1155/2015/732596

Authors: Danielle R. Bruns, Joshua C. Drake, Laurie M. Biela, Frederick F. Peelor, Benjamin F. Miller, Karyn L. Hamilton

Institution: Colorado State University

Language: English

Topic: Genetics, Aging, and Longevity in Model Organisms

Subfield: Aging

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $2,680