Retrograde Response, Oxidative Stress, and Cellular Senescence
Year: 2008
Type: book-chapter
Abstract: SummaryMitochondria are major sources of reactive oxygen species (ROS) in cells, and they have been proposed to have an important role in cellular ageing. Recent evidence suggests that these organelles play a causal role in telomere-dependent senescence of human cells in culture. However, the relation between mitochondrial ROS production and replicative senescence might be more complicated than just simple cause and effect, because mitochondrial dysfunction has been shown to induce a variety of genes involved in nuclear-mitochondrial cross talk. Evidence suggests that this retrograde response might have an important, yet still relatively unexplored role in cell ageing, affecting mitochondrial function, ROS production, and, consequently, the life span of cells.
Source: Humana Press eBooks
Authors: João F. Passos, Thomas von Zglinicki
Institution: Newcastle University
Language: English
Subfield: Molecular Biology
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W71014362