Year: 2025
Type: conference-abstract
Abstract: Structure and fragment based drug discovery campaigns (SBDD and FBDD) rely on frequent access to high resolution protein-ligand structures, in order to support the design-make-test-analyse cycle. Protein crystallography is widely used to support such medicinal chemistry campaigns, but in recent years electron cryo-microscopy (cryo-EM) has emerged as alternative approach that may be applied to proteins that are recalcitrant to crystallisation. In this talk I will describe the advances that have enabled this, provide an illustration of how Astex uses cryo-EM to support drug development and reflect upon the additional developments that will be required if cryo-EM is to reach its full potential in both SBDD and FBDD.
Source: Structural Dynamics
DOI: 10.1063/4.0000881
Author: Pamela A Williams
Institution: Astex Pharmaceuticals
Language: English
Subfield: Structural Biology
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,200
OpenAlex ID: W7101448333
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