Dysbiotic Gut Microbiota Correlates with Altered Serum and Urinary Biomarkers in Recurrent Calcium Oxalate Stone Patients
Year: 2025
Type: article
Abstract: Baolin Zhang,1 Ting Li,2 Ziyang Qiang,1 Lan Ma,3 Xiangfeng Kong,1 Shuang Chen1 1Department of Urology, Qinghai University Affiliated Hospital, Xining, Qinghai, 810000, People’s Republic of China; 2School of Pharmacy, Medical College of Qinghai University, Xining, Qinghai, 810000, People’s Republic of China; 3Clinical Teaching and Research Section, Qinghai Health Vocational and Technical College, Xining, Qinghai, 810000, People’s Republic of ChinaCorrespondence: Ziyang Qiang, Email [email protected]: To explore associations between gut microbiota composition, blood/urine biochemical markers, and recurrent calcium oxalate stones, identifying potential risk factors.Methods: A retrospective study compared 88 patients (≥ 2 stone episodes, 2023– 2025) with 90 age/gender-matched controls. Fecal 16S rRNA sequencing assessed microbial diversity, alongside blood lipid profiles, creatinine, uric acid, and 24-hour urine analysis. Multivariate logistic regression identified independent predictors.Results: Baseline demographics were comparable (P > 0.05). Patients exhibited higher Escherichia coli and Fusobacterium, lower Faecalibacterium and Lachnospira (P < 0.05). Elevated triglycerides, creatinine, reduced HDL-C, and lower urinary magnesium/citrate (P < 0.05) were observed. Spearman analysis linked E. coli abundance to higher creatinine (r = 0.598) and lower HDL-C (r = − 0.607), while Faecalibacterium inversely correlated with creatinine (r = − 0.624; all P < 0.05). Logistic regression identified E. coli abundance, serum creatinine, and urinary magnesium as independent recurrence risk factors (P < 0.05).Conclusion: Gut microbiota dysbiosis correlates with metabolic and urinary abnormalities in recurrent stone formers. Monitoring E. coli levels and biochemical parameters may aid recurrence prediction.Keywords: calcium oxalate nephrolithiasis, gut microbiota, biochemical indicators, hyperoxaluria, influencing factors
Authors: Zhang B, Li T, Qiang Z, Ma L, Kong X, Chen S
Institution: Qinghai University
Language: English
Subfield: Pulmonary and Respiratory Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7102330386
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