Work

Influence of androgen deprivation therapy on physical performance and muscle strength in prostate cancer patients — a systematic review

Year: 2025

Type: review

Abstract: The aim of this study was to assess the impact of androgen deprivation therapy (ADT) on muscle strength and physical performance in prostate cancer (PC) patients. The systematic search was carried out across four databases: PubMed, Embase, Web of Science, and Scopus. Out of 5239 studies, 6 were included, where the standardized functional tests assessing functional mobility were used. The protocol was registered on PROSPERO. Data indicated that the grip strength decreases most rapidly at the beginning of ADT therapy and does not return to its initial values. The gait speed decreases with the duration of ADT and indicates that the patients are at increased risk of adverse outcomes. According to the Short Physical Performance Battery and the time Up and Go test results PC patients present good performance and good mobility. Changes in muscle strength and physical performance in PC patients undergoing ADT are visible and need attention of professionals to prevent further body composition changes.

Source: Reports of Practical Oncology & Radiotherapy

DOI: 10.5603/rpor.108010

Authors: Zuzanna Szarzyńska, Igor Barczak, Karol Giermek, Aleksandra Garczyk, Marcin Mardas, Marta Stelmach-Mardas

Institution: Poznan University of Medical Sciences

Language: English

Topic: Nutrition and Health in Aging

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,713