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Consideration of missing values in sample size calculation for clinical trials using multiple imputation

Year: 2025

Type: conference-paper

Abstract: Introduction: Sample size calculation plays a major role in the planning of a clinical trial. When missing values are expected, a common practice is to inflate the calculated sample size by an estimated dropout rate in order to maintain the desired power. However, it is recommended to include patients [for full text, please go to the a.m. URL]

Source: German Medical Science (German Research Foundation)

DOI: 10.3205/25gmds074

Authors: Byczkowski, Teresa, Kirchner, Marietta, Kieser, Meinhard

Institution: Heidelberg University

Language: English

Topic: Statistical Methods in Clinical Trials

Subfield: Statistics and Probability

Field: Mathematics

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7103882693

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