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Leveraging a genetic proxy to investigate the effects of lifelong cardiac sodium channel blockade

Year: 2025

Type: conference-paper

Abstract: Introduction: Cardiac arrhythmias, most notably atrial fibrillation (AFib), pose a significant global health burden with limited preventive strategies. The SCN5A gene, encoding the cardiac sodium channel Nav1.5, is crucial for heart rhythm, with variants linked to various arrhythmias. The Finnish-enriched [for full text, please go to the a.m. URL]

Source: German Medical Science (German Research Foundation)

DOI: 10.3205/25gmds003

Authors: Wanner, Julian, Krafft, Maren, Niiranen, Teemu, Zimmerman, Dominic, Ellinor, Patrick, Nadkarni, Girish, Jurgens, Sean, Rämö, Joel, Heyne, Henrike

Institutions: Hasso Plattner Institute, University of Potsdam, Finnish Institute for Health and Welfare, Amsterdam University Medical Centers, University of Amsterdam, Broad Institute, Harvard University

Language: English

Topic: Cardiac electrophysiology and arrhythmias

Subfield: Cardiology and Cardiovascular Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7103891081

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