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Unraveling Chondrocyte Death in Tmj Osteoarthritis: Insights Into Programmed Cell Death Mechanisms

Year: 2025

Type: article

Abstract: Temporomandibular joint osteoarthritis (TMJ OA) is a condition characterized by severe pain and joint dysfunction in the temporomandibular joint. The main pathological change in TMJ OA is cartilage degeneration, and chondrocytes are the primary cell type within cartilage tissue. This paper explores the hypothesis that chondrocyte death plays a central role in the process of cartilage degeneration in TMJ OA. Specifically, it focuses on programmed cell death (PCD) as a regulated mechanism involved in the development of OA. The research progress on PCD in OA cartilage degeneration is discussed, offering new insights and ideas for future basic research on cartilage degeneration in TMJ OA.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.17534428

Author: Zhang, Wei Jun

Institution: First Affiliated Hospital of Xinjiang Medical University

Language: English

Topic: Osteoarthritis Treatment and Mechanisms

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7104021132

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