Work

One new rearranged pyranone derivative with antibacterial activity from Xylaria curta YSJ-5

Year: 2025

Type: article

Abstract: The further chemical investigation of the liquid fermentation of endophytic fungus Xylaria curta , which was isolated from the medicinal plant Alpinia zerumbet B. L. Burtt & R. M. Sm., had led to the isolation of one novel compound with the trivial name of xylacurtin A ( 1 ). The chemical structure was fully characterized by means of detailed spectroscopic analysis, which thus successfully revealed it to share an unprecedented 7-butyl-4-methoxyoxepin-2(5 H )-one skeleton. It represents the first member of rearranged pyranone derivative with a novel seven-membered ring system in nature. Moreover, the biological activity of xylacurtin A ( 1 ) were also evaluated to show that 1 was a promising antibacterial lead compound towards the Staphylococcus aureus and Methicillin-resistant S. aureus with the MIC value of 6.3 μg/mL without any notable cytotoxicity.

Source: Phytochemistry Letters

DOI: 10.1016/j.phytol.2025.104075

Authors: Shan-Shan Wei, Dao-Jun Rong, Jia-Ying Lai, Chen Chen, Si-Ran Li, Zhong-Hua Yu, Hai-Bo Tan

Institutions: Chinese Academy of Sciences, South China Botanical Garden, Guangdong Eco-Engineering Polytechnic

Language: English

Topic: Microbial Natural Products and Biosynthesis

Subfield: Pharmacology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $3,520