Dimensional Convergence as a Universal Coherence Metric: From Quantum Physics to Cancer Field Organization
Year: 2025
Type: article
Abstract: Cancer disrupts tissue organization through the loss of coherent bioelectric–morphological coupling, yet existing biomarkers capture molecular rather than field-scale coherence. We apply Dual Boundary Condition Inference (DBCI), a time-symmetric framework that quantifies dimensional collapse—the joint minimization of field gradients and morphological entropy—as a measurable indicator of pathological field disruption. Validation across seven experimental tiers establishes DBCI coherence as a scale-invariant principle. Molecular simulations (H₂, CH₂, NADH, p53) show entropy reduction ΔH ≈ 0.1–0.2 bits under dual-boundary (ABL) reweighting. Clinical inference (breast cancer classification and breath metabolomics; N = 115–569) demonstrates improved discrimination (AUROC = 0.994–0.995) with identical entropy signatures. Cellular validation (N = 4,969 fluorescence micrographs) reveals strong global anticorrelation between bioelectric potential gradients and morphological entropy (ρ = −0.676, p < 10⁻⁵⁰⁰), and tissue-level coherence (ρ_image = −0.633, p < 10⁻¹⁶²). Local (per-ring) measurements yield null correlations (ρ ≈ 0), whereas global (whole-cell) integration produces robust coupling—confirming that dimensional collapse is an emergent, top-down property consistent with the Aharonov–Cohen theorem in quantum foundations [1]. This cross-scale coherence defines a quantitative metric for pathological field organization, offering direct applications in cancer detection and therapy monitoring.
Authors: Razo, Luis, Cumeras, Raquel, Cohen, Eliahu
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7105210844
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