Work

The significance of Circadian Rhythms in Regulating Immune Function and its Implications for Autoimmune Diseases

Year: 2024

Type: article

Abstract: Circadian rhythms are endogenous; near-24-hour biological cycles that regulate diverse physiological processes, including immune function. These rhythms, orchestrated by central and peripheral molecular clocks, profoundly influence immune system dynamics, including leukocyte trafficking, cytokine secretion, and adaptive immune responses. Disruption of circadian rhythms, whether through genetic mutations, environmental influences, or lifestyle factors, has been increasingly implicated in the pathogenesis of autoimmune diseases. This review explores the intricate relationship between circadian biology and immune regulation, focusing on its role in autoimmune disease progression. We discuss emerging strategies, including chronotherapy, lifestyle modifications, and novel therapeutic targets, that leverage circadian principles to improve autoimmune disease management.

Source: Zenodo (CERN European Organization for Nuclear Research)

DOI: 10.5281/zenodo.17588846

Authors: Javed Hussain Bhat, Soobia Rashid, Mohd Abass Dar, Kashif Naem Siddiqqi

Institutions: Sher-i-Kashmir Institute of Medical Sciences, Government Medical College

Language: English

Topic: Circadian rhythm and melatonin

Subfield: Endocrine and Autonomic Systems

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7105519510