Pancreatic solid pseudopapillary neoplasm: Case report of an uncommon tumor and a brief review of the literature
Year: 2025
Type: article
Study design: Case Report
Abstract: Solid pseudopapillary neoplasm (SPN), also called Frantz tumor, is a low-grade pancreatic neoplasm with low malignant potential and is mostly found in young women. It may be a diagnostic challenge because it is rare and often presents with nonspecific symptoms. A 22-year-old woman reported progressive pain in the left upper quadrant of her abdomen, early satiety, and slight weight loss in the last three weeks. The physical examination revealed a tender, palpable mass. Abdominal CT and MRI showed that a big, 8.5 cm, well-encapsulated, heterogeneous solid and cystic mass was present in the tail of the pancreas, which is typical of an SPN with hemorrhagic and necrotic components. This patient had a splenectomy and a distal pancreatectomy. The diagnosis was confirmed using histopathology, which revealed a neoplasm with solid and pseudopapillary structures. Immunohistochemistry was positive for β-catenin and CD10. The surgical margins were negative, and the Ki-67 index was low (2%). The patient managed to recover without issues and is still in the disease-free period 16 months after surgery. The case is a typical example of SPN presentation, emphasizing the necessity of considering typical clinical and radiological features to diagnose it properly and perform a timely surgery. Most cases can be treated by performing an entire surgical resection, which provides a good long-term prognosis.
Authors: Macia, Montserrat, Gianni, Isabella, Naser, Sara, Ayad, Mareena, Hanna, Peter, Jahoda, Jessica, Aziz, Mohamed
Language: English
Subfield: Oncology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7105799202
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