Evaluation of Soft Tissue Healing After Tooth Extraction Using Manuka Honey Gel in Diabetic Patients – a Prospective Study
Year: 2025
Type: article
Study design: Clinical Trial
Abstract: Background: Delayed wound healing after tooth extraction is a common concern in diabetic patients due to impaired collagen synthesis, reduced angiogenesis, and compromised immune response. Natural agents such as Manuka honey have demonstrated antimicrobial and tissue-regenerative properties that may accelerate healing. Aim: To evaluate the efficacy of Manuka honey gel on soft tissue healing following tooth extraction in diabetic patients compared with conventional saline care. Materials and Methods: A prospective clinical study was conducted on 24 controlled type 2 diabetic patients requiring single-tooth extractions. Patients were randomly allocated into two groups: Group A (n = 12) received Manuka honey gel applied directly to the socket after extraction, while Group B (n = 12) received standard saline irrigation and routine care. Healing was assessed on postoperative days 1, 3, 7, and 14 using the Landry, Turnbull, and Howley healing index, Visual Analogue Scale (VAS) for pain, and evaluation for inflammation or infection. Statistical analysis was performed using Student’s t-test and Chi-square tests with p < 0.05 considered significant. Results: Group A showed faster wound epithelialization and significantly higher mean healing scores at all follow-up intervals (p < 0.05). Pain reduction was notably greater in the Manuka group by day 3 (mean VAS 2.1 ± 0.6) compared with control (3.6 ± 0.8). No postoperative infections were reported in the Manuka group, while two cases occurred in the control group. Conclusion: The application of Manuka honey gel after tooth extraction in diabetic patients significantly enhances soft tissue healing, reduces inflammation, and promotes patient comfort. It can serve as a safe and cost-effective adjunct for wound management in medically compromised individuals. Keywords: Manuka honey, diabetic patients, wound healing, tooth extraction, soft tissue repair
Authors: Dr. S Anand Vijay MDS, Dr. Harika, Dr.Musunuri Manoj Kumar MDS, FTMJF RCSEd, Dr. N Jyothirmai, Dr. B Sandeep Paul, Dr. K Pranathi
Language: English
Subfield: Insect Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7105804186
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