Formulation and Evaluation of Ketoconazole Spanlastics Gel
Year: 2025
Type: article
Abstract: Ketoconazole is administered to treat fungal infections. It has a restricted pharmacological purpose due to its low aqueous solubility, which lowers the drug's bioavailability. Also, oral ketoconazole causes major systemic side effects on the human body. As a result, topical ketoconazole treatment is favored over oral ketoconazole. The current study was carried out to develop and assess a ketoconazole-loaded spanlastic gel. Spanlastic was created utilizing the ethanol injection process, utilizing Span 60 and Tween 80 serving as non-ionic surfactants and edge activators, respectively. The formulation was examined for several parameters, including particle size, entrapment efficiency, and surface charge. The formulation demonstrated lower particle size and a higher entrapment efficiency of 99.90±0.02%. The Zeta potential of spanlastics was found to be -23mv. The spanlastic formulation was mixed into a gel made with 1% w/w Carbopol 934 and tested for various parameters. The produced gel was homogeneous and contained 92.64±0.02 mg/ml. Stability investigations revealed that ketoconazole-loaded spanlastic gel was stable. As a result, we can infer that the proposed formulation is a potential delivery strategy with improved efficacy, controlled release, and patient compliance.
Author: Sayan Das*1, Pritam Kundu1, Subhashini B. Hawaldar1, Anju K. P.2
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7105857220
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