The hemodynamic performance of transcatheter heart valve in bileaflet mechanical valve: An in-Vitro study.
Year: 2025
Type: article
Abstract: Objectives This study evaluates the haemodynamic performance of a novel hybrid configuration-Valve-in-MHV-where a CoreValve transcatheter heart valve is implanted within the annulus of a composite valved graft after leaflet removal. Methods in vitro testing was performed using left heart mock loop combined with backlight Particle Image Velocimetry. Three configurations were assessed: (i) mechanical heart valve (MHV), (ii) CoreValve THV, and (iii) Valve-in-MHV. Flow parameters were measured at cardiac outputs of 3 and 5 L/min. Results At 5 L/min, the Valve-in-MHV showed the highest PG (15.5 mmHg) and TKE (0.53 m2/s2), compared to the THV (10.9 mmHg, 0.31 m2/s2) and MHV (11.5 mmHg, 0.26 m2/s2). EOA was smallest for the Valve-in-MHV (1.44 cm2). The Valve-in-MHV generated a more physiological central jet than the MHV, but with increased turbulence and higher peak velocities (up to 2.66 m/s). Conclusions Examining the mechanistic implications of Valve-in-MHV may offer valuable insights into the likelihood of adverse effects such as leaflet thrombosis and the development of pronounced pressure gradients in patients who are candidates for Valve-in-MHV.
DOI: 10.48620/92394
Authors: Catalano, Chiara, Pasta, Salvatore, Potratz, Paul, Buffle, Eric, Siepe, Matthias, Obrist, Dominik
Language: English
Subfield: Cardiology and Cardiovascular Medicine
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7105921547
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