Acute Oral Toxicity Study of Karmarangadi Leha in Wistar Albino Rats
Year: 2025
Type: article
Abstract: Karmarangadi leha is herbal compound formulation used by folklore practitioners for treatment of respiratory disorders, especially Kaphaja kasa. However, till date, no safety profile of this formulation has been reported. Hence in present study freshly prepared sample of Karmarangadi leha was evaluated for acute toxicity. Acute oral toxicity test was evaluated as per OECD 425 guidelines with 2000 mg/kg as limit test in wistar albino rats. Test formulation was administered to overnight fasted animals and parameters like body weight, behavioural changes, mortality were assessed for 14 days. Results showed no significant changes in terms of behavioural changes, morbidity and body weight. Hence this study shows that sample of Karmarangadi leha is relatively safe up to the dose of 2000 mg/kg.
Author: Raksha Bhat H.1*, Nagaratna S. Jartarghar2, Chithralekha3, Ravikrishna4, Sudhakar Bhat5
Language: English
Subfield: Plant Science
Domain: Life Sciences
Open Access status: hybrid
OpenAlex ID: W7105991559
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