Preparation and Evaluation of Solid Dispersions of Telmisartan for Enhanced Solubility: a Comprehensive Review
Year: 2025
Type: article
Abstract: The ability to resolve the issue of solubility of poorly soluble drugs in water is a constant task for the creation of medicines. An example of this is the telmisartan - a popular antihypertensive drug. The present review highlights a thorough assessment of solid dispersion method that can be potentially used to treat telmisartan low solubility in water. The issues presented in the review include an introduction of physicochemical properties of telmisartan and the possible barriers in the dissolution and absorption of drug, alongside a theoretical description and justification of solid dispersion method. Special attention is put on the appearance of carriers, method of preparation and characterization parameters that hold a significant role in determining telmisartan stability and efficiency. The review systematically analyzes the progress of formulation strategies to the solid dispersion method used to enhance telmisartan oral bioavailability showing its pragmatic value and prospects.
Author: Nibedita Pradhan1*, Nancy Mohapatra2, Pruthwiraj Dash3, Pratik Panda4, Monoranjan Sahu5, Sonali Behera6, Pratik Kumar Sahu7
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
OpenAlex ID: W7105997694
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