Work

Decoding the oral-flavor axis: from fundamental mechanisms to precision modulation for enhancing flavor perception

Year: 2025

Type: article

Abstract: • Systematically reviewing the pivotal role of OE in shaping flavor perception. • Summarizing recent advances in the regulatory mechanisms of OE and modulation approaches to enhance flavor perception. • Highlighting the potential of bioactives for precision modulation and targeted optimization • Proposing the integration of machine learning and multi-omics approaches for personalized OE modulation. The oral ecosystem (OE) is a critical yet underexplored interface where food components interact with host physiology to shape flavor perception. This comprehensive review summarizes current knowledge on OE-flavor interactions through a hierarchical framework: (1) oral secretion-mediated flavor release and modification; (2) microbiota-driven flavor biotransformation; and (3) dynamic feedback loops between oral secretion and oral microbiota. We further critically evaluate emerging strategies for precision OE modulation, focusing on natural bioactives that target specific microbial guilds. Furthermore, we propose additional efforts in integrating multi-omics profiling with machine learning algorisms for data-driven personalized OE modulation. This work provides actionable insights into OE-tailored strategies in developing future foods with enhanced sensory experiences.

Source: Journal of Future Foods

DOI: 10.1016/j.jfutfo.2025.11.006

Authors: Tong Wu, Haojie Ni, Youming Tan, Ying Sun, Baosong Wang, Song Miao, Dongxiao Sun-Waterhouse, Hong Zeng, Yanbo Wang

Institutions: Beijing Technology and Business University, Teagasc - The Irish Agriculture and Food Development Authority, University of Auckland

Language: English

Topic: Biochemical Analysis and Sensing Techniques

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Zero hunger

Open Access status: diamond

Funder: National Natural Science Foundation of China