Fabrication and characterization of polycaprolactone/chitosan oligomer fibrous membrane by electrospinning technique for wound dressings applications
Year: 2025
Type: article
Abstract: Electrospun nanofibrous membrane is a promising approach to wound care, providing a versatile platform for developing advanced wound dressings that accelerate healing and improve patient outcomes. In this study, nanofibrous membranes are fabricated by blending chitosan oligomer (COS) and polycaprolactone (PCL). The highest blendable COS concentration to make defect‐free fibers is 20 wt%, corresponding to PCL content. The addition of COS reduces the contact angle of the membrane. The incorporated COS reduces the fiber's diameter while increasing the fabricated membrane's mechanical properties. Furthermore, the in vitro experiment results indicate that the PCL/COS could enhance the healing process. However, the membrane shows non‐antibacterial properties due to insufficient COS in the membrane and a slow COS release rate.
Source: Vietnam Journal of Chemistry
DOI: 10.1002/vjch.70095
Authors: Khoi Minh Le, Khiem Van Nguyen, Vinh Thanh Luong, My‐An Le Tran, Phan Thi Thanh Tam, Thi Thu Tram Nguyen, Thi‐Hiep Nguyen, Phu Phong Vo, Hoan Ngoc Doan
Language: English
Subfield: Biomaterials
Field: Materials Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,400
OpenAlex ID: W7106270791