Work

Untensed fibronectin fibers: a novel hallmark of microthrombi

Year: 2025

Type: article

Abstract: These findings underscore FnBPA5's unique capacity to discriminate not merely the presence of an abundant ECM molecule within a thrombus, but its distinct physical conformation. FnBPA5 enables the selective detection of microthrombi in coronary arteries by targeting untensed fibronectin fibers, a novel mechanical biomarker of microthrombi. Targeting a protein's physical state with high specificity makes FnBPA5 a promising tool for advanced microthrombi detection and for mechano-therapeutic strategies involving the targeted delivery of therapeutic agents.

Source: Zurich Open Repository and Archive (University of Zurich)

DOI: 10.5167/uzh-279818

Authors: Miéville, Arnaud, Wolint, Petra, Cesarovic, Nikola, Falk, Volkmar, Vogel, Viola

Language: English

Topic: Blood properties and coagulation

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7106334391

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